Technology

The skin, a living organ capable of regenerating itself

The skin is, along with the liver, the only organ in the human body capable of regenerating itself. However, with age and external aggressions, this self-repair capacity decreases, the skin loses its firmness and radiance and the first wrinkles appear. The only action on the surface of classic cosmetics is then no longer sufficient to fight against the signs of aging.
To effectively relaunch these self-regeneration mechanisms, it is necessary to mobilize all the skin layers, including the deepest ones to have a global action.

The Lightinderm solution: the unique combination of 3 technologies

For the first time, Lightinderm synergistically combines 3 technologies for a triple stimulation of the skin:

- Energetic stimulation with regenerating lights
- Biological stimulation with photoactive serums
- Mechanical stimulation with tissue massage

And the results are there, scientifically proven, an effectiveness multiplied by 3 compared to a classic serum on all signs of aging.

Light, regenerative energy used in dermatological practice

It has been widely demonstrated that the skin responds to the stimulation of light, thanks to photoreceptors present in the cells. A very short exposure to low-intensity light triggers a series of reactions that will have lasting consequences on cell biology: energy supply, protein synthesis, cell regeneration. This is called photobiomodulation.

Light is used in particular in dermatological practices to promote healing and post-procedure recovery, but also to improve the quality of the skin, fight against the signs of aging and treat acne.

Lightinderm, scientifically validated light combinations

The Lightinderm research program began at Cochin Hospital with more than 375 in vitro tests.
Its objective: to determine the wavelengths having the best effects on the cells.

11 wavelengths were preselected, followed by a series of tests:
- Association of different wavelengths
- Comparison of the effect of intensities
- Comparison of illumination times
- Development of the most effective pulse patterns.

Example: the blue light + Photolyase synergy to fight against photo-aging

This synergy was the subject of a Nobel Prize in 2015 and has been extensively studied by Lightinderm to define the optimal parameters and dosages to ensure the greatest efficiency.
Exposure to UV causes damage to the heart of the skin cells, which subsequently induces degradation of the dermis and therefore skin aging.
Lightinderm research capitalizes on the cell repair capacities of a photo-active plankton extract: photolyase.
This enzyme, once activated by blue light, repairs cellular damage caused by UV. Day after day, the cells repair themselves and regain optimal functioning, the signs of aging fade.

Effective mechanical stimulation

All cells of the dermis and epidermis are sensitive to massage. Mechanical stimulation is at the origin of a detectable and measurable signal, which triggers a now well-known cellular activation, mechanotransduction.
The action of the massage is particularly interesting in the context of Lightinderm because it perfectly complements that of the lights combined with the photoactive serums.

Density, firmness and radiance of the complexion

With its mechanical pressure, the massage puts tension on the extracellular matrix, ensuring the remodeling of the dermis. Tension promotes the production and organization of collagen isotypes allowing a solid intercellular mesh. The skin is denser and firmer.
The massage also improves microcirculation, promoting the supply of nutrients and oxygen for a more radiant complexion.

More than 450 in vitro studies

Lightinderm carries out laboratory research on human cell cultures in order to discover the optimal light parameters, effectively combine wavelengths and above all associate them with active ingredients in order to potentiate their effects.

More than 25 ex vivo pre clinical studies

The in vitro results are then evaluated on models of skin explants kept alive or reconstructed skin in order to validate the effects of the treatment on the different layers of the skin and to study the mechanisms of action.

5 clinical studies on more than 150 women: proven efficacy and safety

The efficacy and safety of all Lightinderm treatments are clinically proven, thanks to studies carried out by independent laboratories under dermatological control.
Four levels of assessment are carried out: instrumental measurements, clinical assessment by a dermatologist, scoring by a panel of experts and self-assessment by the volunteers.